Savesta ThinkWellThis innovative blend of Ayurvedic herbs combined with the nutriceuticals Phosphatidylserine (PS) and Vinpocetine works fast to support healthy brain function and clear thinking.*
The Science of ThinkWell
Bacopa (Bacopa monnieri) is a succulent ground creeper with white to violet or pale blue flowers and is found throughout India in wet areas. Traditionally used in Ayurveda to enhance memory, studies have shown that oral administration of Bacopa to normal rats significantly improves memory and learning ability1 and inhibits free radical damage to brain cells in vitro.2 Increased learning ability and memory was demonstrated in normal rats orally administered active constituents of Bacopa known as bacosides.3,4 Double-blind, randomized, placebo-controlled studies of Bacopa using well-validated tests in healthy adults have shown that daily use increases the retention of new information,5,6 the learning rate, and the rate that visual information is processed.6
Gotu Kola (Centella asiatica) is an edible creeper with light violet flowers. Like Bacopa, Gotu kola is is found in moist tropical areas throughout India and is traditionally used in Ayurveda to enhance memory.7 Got kola has also been used promote mental calm and relaxation during meditation.8 Studies show that orally administered to normal rats, Gotu kola significantly increases memory,9,10 learning ability, antioxidant activity in the brain9 and resistance to psychological and physical stress.11,12 In a randomized, double-blind, placebo-controlled study, healthy men and women given a single oral dose of Gotu kola extract showed a significantly reduced response to acute stress.8
Phosphatidylserine (PS) (fos-fa-tidle-serine) is derived from soy lecithin. Rats fed PS daily showed significantly enhanced cognitive abilities.13 In a randomized double-blind, placebo-controlled study in healthy men and women, PS (400 mg/day taken with meals) produced a significant decrease in the level of psychological stress in response to emotional and mental stressors. A further benefit was found in their levels of the stress hormone cortisol which were significantly dampened in response to the stressors.14
Vinpocetine (‘vin-po-se-teen’) is derived from an alkaloid found in the leaves of lesser periwinkle (Vinca minor). In healthy adults, an oral dose of Vinpocetine improved the flow of red blood cells.15 In vitro, Vinpocetine was found to act as an antioxidant that scavenges oxygen free radicals.16,17 Tests using isolated brain cells have shown that Vinpocetine protects against damaging effects of free radicals 17-19 and low oxygen levels.20,21 Taken orally by healthy adults, Vinpocetine enters the brain after only ten minutes.22 However, for greatest bioavailability it is best taken 60 minutes after a meal.23
1 capsule, 3 times per day (after meals) or as directed by your health care practitioner.
Caution: Not to be taken by individuals taking prescription drugs without the advise of a physician. Not to be combined with anticoagulant medications (e.g., high-dose aspirin). Not for use during pregnancy. If you are nursing or taking any prescription drugs, seek the advice of a health professional before using this product. Keep out of reach of children.
Care for the Environment
As a manufacturer, our actions can have a large impact on the environment. We always look for the most earth-friendly, sustainable choice.
Avesta products feature:
- Vegan capsules and tablets, no animal derived ingredients
- Organic cotton stuffing and easily recyclable #2 HDPE plastic bottles
- Plant extracts made with pure water and alcohol, no toxic solvents
- We feature sustainably wild-crafted herbs grown without chemical pesticides or fertilizers
- No GMO ingredients
- Non-irradiated herbs
- Soy, wheat and gluten free
- Singh HK, Dhawan BN. Effect of Bacopa monniera Linn. (Brahmi) extract on avoidance responses in rat. J Ethnopharmacol. 1982;5(2):205-214.
- Russo A, Acquaviva R, Borrelli F, Campisi A, Raciti G, Vanella A. Nitric oxide-related toxicity in cultured astrocytes: Effect of Bacopa monniera. Life Sci. 2003;73(12):1517-1526.
- Singh HK, Rastogi RP, Srimal RC, Dhawan BN. Effect of bacosides A and B on avoidance responses in rats. Phytother Res. 1988;2(2):70-75.
- Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol. 1997;29(5):S359-S365.
- Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallewf C, Smoker J. Chronic effects of brahmi (Bacopa monniera) on human memory. Neuropsychopharmacol. 2002;27(2):279-281.
- Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology. 2001;156(4):481-484. Gotu kola
- Kirtikar KR, Basu BD, An ICS. Indian Medicinal Plants. Vol. 2. 2nd ed. Dehra Dun, India: Bishen Singh Mahendra Pal Singh; 1993:1193-1195.
- Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of gotu kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol. 2000;20(6):680-684.
- Rao MKG, Rao MS, Rao GM. Centella asiatica extract enhances learning – correlation with hippocampal structural changes. Indian J Pharmacol. 2000;32:149 (abstr).
- Veerendra Kumar MH, Gupta YK. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J Ethnopharmacol. 2002;79(2):253-260.
- Sarma DNK, Khosa RL, Chansauria JPN, Sahai M. Antistress activity of Tinospora cordifolia and Centella asiatica extracts. Phytother Res. 1996;10(2):181-183.
- Sakina MR, Dandiya PC. A psychoneuropharmacological profile of Centella asiatica extract. Fitoterapia. 1990;61(4):291-296. Phosphatidylserine
- Blokland A, Honig W, Brouns F, Jolles J. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition. 1999;15(10):778-783.
- Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004;7(2):119-126. Vinpocetine
- Hayakawa M. Effect of vinpocetine on red blood cell deformability in vivo measured by a new centrifugation method. Arzneim-Forsch. 1992;42(3):281-283.
- Olah VA, Balla G, Balla J, Szabolcs A, Karmazsin L. An in vitro study of the hydroxyl scavenger effect of Cavinton. Acta Paediatr Hung. 1990;30(2):309-316.
- Santos MS, Duarte AI, Moreira PI, Oliveira CR. Synaptosomal response to oxidative stress: Effect of vinpocetine. Free Radic Res. 2000;32:57-66.
- Horvath B, Marton Z, Halmosi R, Alexy T, Szapary L, Vekasi J, Biro Z, Habon T, Kesmarky G, Toth K. In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. Clin Neuropharmacol. 2002;25:37-42.
- Pereira CA, Agostinho P, Moreira PI, Duarte AI, Santos MS, Oliveira CR. [Neuroprotection strategies: Effect of vinpocetine in vitro oxidative stress models]. Acta Med Port. 2003;16(6):401-406 (in Portuguese with English abstr).
- DeNoble VJ, Repetti SJ, Gelpke LW, Wood LM, Keim KL. Vinpocetine: nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats. Pharmacol Biochem Behav. 1986;24(4):1123-1128.
- Gabryel B, Adamek M, Pudelko A, Malecki A, Trzeciak HI. Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation. Neurotoxicology. 2002;23:19-31.
- Gulyas B, Halldin C, Sovago J, Sandell J, Cselenyi Z, Vas A, Kiss B, Karpati E, Farde L. Drug distribution in man: a positron emission tomography study after oral administration of the labeled neuroprotective drug vinpocetine. Eur J Nucl Med Mol Imaging. 2002;29(8):1031-1038.
- Lohmann A, Dingler E, Sommer W, Schaffler K, Wober W, Schmidt W. Bioavailability of vinpocetine and interference of the time of application with food intake. Arzneim-Forschung. 1992;42(7):914-917.
Please remember that this information is not meant to substitute for a consultation with your physician, or another health care professional. Speak with your doctor if you have questions about primary care, or about any medical problem.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease, but rather are dietary supplements intended solely for nutritional use.