CON-CRET
CON-CRET is the world’s first and only concentrated creatine. This specially conjugated creatine contains no calories, no fillers, no sugar and gains its competitive advantage from its delivery mechanism – known as micro-dosingTM – defined as, 1/4 teaspoon per 100-pounds of bodyweight.
CON-CRET was designed for those that are serious about their conditioning and want a competitive advantage. Many athletes have tried creatine and experienced the strength, mass and muscle it can provide, but don't like its negative side effects.
The CON-CRET molecule is a technological breakthrough that is the result of four years of corporate research, Division 1-A university laboratory development, and real-world testing. This effort produced a highly concentrated form of creatine where the need for loading is eliminated and the overall dose required is significantly low.
CON-CRET uses bonding molecules that have been effectively and safely used in the pharmaceutical industry for years. This patent-pending conjugation is at the heart of this revolutionary approach to the creatine market. For the first time, users gain all of the benefits associated with creatine while eliminating the negative side-effects that have historically plagued other products. CON-CRET is not creatine monohydrate nor is it an ester creatine.
The box states that CON-CRET is a, “Specially Conjugated Creatine,” what does that mean? Conjugated means “bound” – it is simply a scientific term for molecules being bonded together. As stated above, CON-CRET uses bonding molecules that have been effectively and safely used in the pharmaceutical industry for years. This patent-pending conjugation is what provides such superior performance for CON-CRET in terms of potency and solubilityperformance for CON-CRET in terms of potency and solubility.
Creatine is nitrogenous organic acid which naturally occurs in vertebrates and helps to supply energy to muscle and nerve cells. Creatine was identified in 1832 when Michel Eugène Chevreul discovered it as a component of skeletal muscle which he later named creatine after the Greek word for flesh, Kreas. Creatine, by way of conversion to and from phosphocreatine, is present and functions in all vertebrates, as well as some invertebrates, in conjunction with the enzyme creatine kinase. A similar system based on arginine/phosphoarginine operates in many invertebrates via the action of Arginine Kinase. The presence of this energy buffer system keeps the ATP/ADP ratio high at subcellular places where ATP is needed, which ensures that the free energy of ATP remains high and minimizes the loss of adenosine nucleotides, which would cause cellular dysfunction.
In the human body, approximately half of the daily creatine is biosynthesized by the use of parts from three different amino acids - arginine, glycine, and methionine. The rest is taken in by alimentary sources mainly from fresh fish and meat. 95% of it is later stored in the skeletal muscles, with the rest in the brain, heart, testes, inner ear hair cells and other organs and cells.
When did creatine become a popularized form of supplementation? Creatine supplements are athletic aids used to increase high-intensity athletic performance. Though researchers have known of the use of creatine as an energy source by skeletal muscles since the beginning of the 20th century, they were popularized as a performance-enhancing supplement in 1992.
Do creatine ester products have less potency than creatine monohydrates? No. In fact, esters usually have more potency because they are more readily bio-available. Esterfication increases potency by about 10x when compared to creatine monohydrate. CON-CRET, however, is a molecular development beyond esters and is significantly more potent than creatine monohydrate.
What is the best manner to evaluate potency when comparing CON-CRET (micro-dosing) to all other forms of creatine (powder, pills, tablets and liquids)? ProMera Health, LLC, the manufacturer and marketer of CON-CRET, has commissioned double-blind research studies to independently evaluate the potency of CON-CRET and other leading creatine products on the market today.
The following Potency Graph provides the results of one of these studies – where creatine monohydrate is the base (or, 0), and each subsequent creatine product type on the market today was studied for comparative potency impact. These results show CON-CRET being nearly 60x’s more potent than creatine monohydrate, and significantly more potent than esters.
This potency translates into a much smaller dosage size while maintaining effectiveness in delivering creatine to the muscle.
What amount of creatine is considered normal in a 200-pound person? In light of the plethora of information put in the market by various vendors to support their products in terms of what should be “loaded” and then “maintained,” from a creatine in-take perspective, what follows is a breakdown of what a typical 200-pound person should consider:
- This person has approximately 160 grams of “free” creatine in their body at any point in time, and is burning about 2.5 grams of free creatine per day
- The body produces approximately 1 gram of creatine per day on its own
- The body then needs the balance of 1.5 grams of creatine per day via diet or supplementation
- More activity / exercise can cause more creatine to be used and therefore needed
Given the inefficiency, or, put another way, the lack of potency, associated with the various creatine products on the market today, it forces these vendors to hype heavy in-take during loading periods. In essence, it is their admission to their own products’ lack of potency, and a marketing ploy to increase usage / dosage, thereby increasing overall demand.
CON-CRET does not require loading, nor does it need to be cycled. As a result of its overall potency and the efficiency of the carrier molecule, CON-CRET eliminates the need for ingesting massive quantities of powders and pills.
How many grams of creatine are in a serving of CON-CRET (on an equivalent basis)? As described above, CON-CRET is delivered via a micro-dosing approach. This dosing approach calls for ¼ teaspoon of CON-CRET for every 100-pounds of body-weight.
A single dose, or ¼ teaspoon of CON-CRET (0.8 grams per serving) is the equivalent in muscle cell potency to 5 – 10 grams of creatine monohydrate. In keeping with our 200-pound example, a ½ teaspoon dose of CON-CRET (1.6 grams per serving) is the equivalent in muscle cell potency of 10 – 20 grams of creatine monohydrate. There is no more simplistic way to illustrate the potency of CON-CRET versus creatine monohydrate than to consider the dosage ratio described here.
Do you recommend stacking CON-CRET with other supplements? Generally speaking, CON-CRET can be stacked with complementary supplements. For example, stacking with whey or protein-based supplements is fairly typical and allows the user to benefit from the unique qualities each of these supplements offers.
We would, however, discourage anyone from stacking CON-CRET with another creatine-based product, or with a product that does not fully disclose their ingredients list.
In developing CON-CRET, was the goal to eliminate the typical negative side-effects associated with other creatines on the market? No. It was not the initial goal. In fact, our development team was focused on increased absorption. In achieving this goal and in-turn developing the micro-dosing approach, our team soon discovered that the overall efficiency of our solution eliminated these negative side effects when taken as directed
We do realize, however, that not everyone shares the same metabolic process. As such, it is important to see how you respond to the recommended dosage. If, for some reason, you do begin to experience negative side-effects, that is simply your body telling you to pull back on the dosage.
What is the main reason why CON-CRET does not produce negative side-effects? As described above, it is the combination of small dosage amounts coupled with the overall efficiency in the absorption of CON-CRET by the body. To put it simply, users do not typically see negative side-effects when taking CON-CRET because there isn’t all the “waste” that remains from other creatines – waste that the body uncomfortably struggles to process (gas, bloating).
As stated above, however, we recognize that not everyone is the same. If for some reason you begin to experience side-effects, it simply means you can further reduce the dosage amount.
Is creatinine the primary cause of side-effects? No. The primary cause is related to the difficulty the body has with excreting large dosage forms of other creatine products and the edema (fluid redistribution) of creatine outside the muscle tissue.
Would you suggest that glucose / dextrose be combined with CON-CRET? No, it is not necessary. Most individuals get plenty of sugar in their daily dietary intake. We only suggest taking CON-CRET with 4-6 ounces of grape or apple juice because, when mixed with these juices, it will create a pleasant tart taste.
Does taking CON-CRET with grape or apple juice create a glucose carrier to assist product delivery into the body’s system as compared to simply taking it with water? As a continuation of the question above, we suggest taking CON-CRET with grape or apple juice simply to help moderate the tartness of the product.
We do not promote, nor do we make any claims regarding the concept of a glucose carrier approach. In fact, our test results show CON-CRET performing equally well regardless of the liquid in which it is dissolved.
What is the pH of CON-CRET? What is the pH of your stomach? What does pH have to do with bio- availability and absorption? pH is a measure of the acidity or alkalinity of a solution. Aqueous solutions at 25°C with a pH less than seven are considered acidic, while those with a pH greater than seven are considered basic (alkaline). When a pH level is 7.0, it is defined as 'neutral' at 25°C because at this pH the concentration of H3O+ equals the concentration of OH- in pure water. pH is formally dependent upon the activity of hydronium ions (H3O+), but for very dilute solutions, the molarity of H3O+ may be used as a substitute with little loss of accuracy. (H+ is often used as a synonym for H3O+). Because pH is dependent on ionic activity, a property which cannot be measured easily or fully predicted theoretically, it is difficult to determine an accurate value for the pH of a solution. The pH reading of a solution is usually obtained by comparing unknown solutions to those of known pH.
With that said, a dose of CON-CRET in 4-6 ounces of a liquid (grape juice, apple juice or water) yields a pH of approximately 2.0, but it does vary with the volume of liquid in which it is dissolved. As shown in the graphic below, the stomach has a pH that can vary between 1.0 and 2.0.
Bio-availability and absorption are effected by pH in that the gastro intestinal (GI) tract is accustomed to dealing with low pH materials and therefore requires no change or differentiated chemistry to process. Put another way, CON-CRET’s low pH is symbiotic to the stomach and the cleaved molecules are a completely natural component of the GI tract. This alignment produces the exceptional bio-availability and absorption rates that have been proven by the superior results experienced by CON-CRET users.
How stable is CON-CRET in water / juice? Results from tests sponsored by ProMera Health, LLC, the manufacturer and marketer of CON-CRET, have shown CON-CRET to be perfectly stable after 60-days in water. We are in the process of further testing these attributes and will update upon receipt of new data.
How important is it that CON-CRET dissolves completely in water? While there are significant studies that examine the percentage of water in the human body, it is widely agreed that the typical male has approximately 69% of their body mass comprised of water. For females, this number is approximately 55% (due to the higher proportion of body fat). Obviously, water is a critical component of life, and instrumental in maintaining health and wellness.
This data points directly to the significance of CON-CRET being soluble and stable in water. In a recent double-blind experiment, our independent researchers completely dissolved 90 grams of CON-CRET in 100mL of water (3.4 fluid ounces). The nearest competitor could only achieve 25 grams being dissolved, and even then there was slight sediment visual. From there, most other creatines on the market could only dissolve 1 gram of product – clearly indicative of their lack of effectiveness and thus the need for loading.
Do you load or cycle with CON-CRET? No. There is no need to load CON-CRET as it is highly soluble and highly potent. As such, it delivers creatine directly to the muscles in a manner that does not require the inefficient process known as creatine directly to the muscles in a manner that does not require the inefficient process known as loading. There is no need to cycle as CON-CRET safely delivers creatine on a consistent and efficient manner, which eliminates the need for cycling.
When can you expect to see results from CON-CRET? Users often report an immediate impact on endurance and recovery. From a strength building and muscle size perspective, our user assessments (volunteers who dosed from 4 to 104 weeks) reflected that 95% of users saw results in the first four weeks of usage with the balance noting results by week five. It is important to note that continued use of CON-CRET is safe and will continue to positively impact endurance, recovery, strength and mass when taken as directed.
Remember, by facilitating strength and recovery, CON-CRET allows you to work-out longer and more effectively so that you can build more muscle. It also can help increase muscle volume by pulling water into the cells for protein synthesis, which, in turn, causes the muscles to be bigger.
Finally, there have been several companies that tout that their creatine products are “micronized” – what are they referring to? Unfortunately, this term tends to be marketing hype. In most cases, the term micronized refers to the difference between using 80 mesh creatine monohydrate and 200 mesh creatine monohydrate. Or, put another way, it is simply ground-down and screened to a finer powder consistency which usually brings along a higher price tag with no significant increase in performance.
Please remember that this information is not meant to substitute for a consultation with your physician, or another health care professional. Speak with your doctor if you have questions about primary care, or about any medical problem.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease, but rather are dietary supplements intended solely for nutritional use.
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